Ruiwen Zhang Selected Research

Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)

4/2016	Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer.
1/2015	Human tumor xenografts in mouse as a model for evaluating therapeutic efficacy of monoclonal antibodies or antibody-drug conjugate targeting receptor tyrosine kinases.
12/2014	Efficacy of anti-RON antibody Zt/g4-drug maytansinoid conjugation (Anti-RON ADC) as a novel therapeutics for targeted colorectal cancer therapy.
9/2013	Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction.
7/2013	MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
5/2013	Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents.
12/2011	Sustained expression of the RON receptor tyrosine kinase by pancreatic cancer stem cells as a potential targeting moiety for antibody-directed chemotherapeutics.

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Ruiwen Zhang Research Topics

Disease

98	Neoplasms (Cancer) 05/2024 - 01/2002
19	Breast Neoplasms (Breast Cancer) 08/2023 - 05/2003
15	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 02/2003
12	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2012
11	Carcinogenesis 05/2024 - 12/2004
11	Pancreatic Neoplasms (Pancreatic Cancer) 12/2018 - 09/2006
6	Glioma (Gliomas) 03/2021 - 03/2004
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2017 - 08/2002
5	Lung Neoplasms (Lung Cancer) 12/2015 - 06/2006
4	Inflammation (Inflammations) 12/2023 - 01/2009
4	Hepatocellular Carcinoma (Hepatoma) 10/2019 - 09/2008
4	Colonic Neoplasms (Colon Cancer) 06/2007 - 04/2002
3	Hypoxia (Hypoxemia) 01/2021 - 02/2005
3	Neuroblastoma 01/2021 - 12/2020
3	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 01/2002
3	Brain Neoplasms (Brain Tumor) 01/2020 - 03/2014
3	Ovarian Neoplasms (Ovarian Cancer) 01/2017 - 07/2009
3	Polyploidy 05/2014 - 05/2013
2	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 12/2023
2	Triple Negative Breast Neoplasms 01/2021 - 03/2017
2	Melanoma (Melanoma, Malignant) 01/2020 - 03/2017
2	Retinoblastoma (Glioblastoma, Retinal) 05/2014 - 09/2003
2	Leukemia 09/2013 - 09/2006
1	Chronic Obstructive Pulmonary Disease (COPD) 02/2024
1	Memory Disorders (Memory Loss) 12/2023
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2022
1	Obesity 10/2021
1	Moyamoya Disease (Moya-Moya Disease) 01/2021

Drug/Important Bio-Agent (IBA)

22	Proteins (Proteins, Gene)FDA Link 03/2021 - 02/2003
14	OligonucleotidesIBA 06/2007 - 01/2002
11	Antisense OligonucleotidesIBA 09/2006 - 04/2002
10	Gemcitabine FDA Link 10/2018 - 03/2004
9	GinsenosidesIBA 01/2018 - 03/2007
8	Oncogene Proteins (Oncogene Protein)IBA 10/2019 - 02/2005
7	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 04/2016 - 12/2011
7	Antineoplastic Agents (Antineoplastics)IBA 07/2015 - 04/2002
6	Messenger RNA (mRNA)IBA 03/2021 - 09/2005
6	Therapeutic UsesIBA 10/2014 - 04/2002
5	Transcription Factors (Transcription Factor)IBA 05/2016 - 01/2005
5	Carboplatin (JM8)FDA LinkGeneric 07/2009 - 03/2004
5	Irinotecan (Camptosar)FDA LinkGeneric 11/2007 - 01/2002
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 05/2002
4	UbiquitinIBA 05/2018 - 03/2007
4	Proto-Oncogene Proteins c-mdm2IBA 01/2018 - 09/2005
4	7- (benzylamino)- 1,3,4,8- tetrahydropyrrolo(4,3,2- de)quinolin- 8(1H)- oneIBA 01/2017 - 07/2010
4	Biomarkers (Surrogate Marker)IBA 12/2015 - 04/2007
4	iminoquinoneIBA 07/2015 - 07/2010
4	7- (4- fluorobenzylamino)- 1,3,4,8- tetrahydropyrrolo(4,3,2- de)quinolin- 8(1H)- oneIBA 05/2012 - 05/2009
4	Dexamethasone (Maxidex)FDA LinkGeneric 03/2009 - 03/2004
4	Docetaxel (Taxotere)FDA Link 06/2008 - 08/2005
3	CytokinesIBA 02/2024 - 04/2007
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 12/2020 - 03/2007
3	6- methoxy- 1- (naphthalen- 1- yl)- 9H- pyrido(3,4- b)indoleIBA 01/2020 - 10/2014
3	indoleIBA 12/2018 - 10/2014
3	artemisinin (artemisinine)IBA 01/2017 - 09/2008
3	25-methoxylprotopanaxadiolIBA 08/2015 - 06/2009
3	Cisplatin (Platino)FDA LinkGeneric 03/2015 - 08/2002
3	Hormones (Hormone)IBA 01/2015 - 02/2005
3	N- (4- (2- amino- 3- chloropyridin- 4- yloxy)- 3- fluorophenyl)- 4- ethoxy- 1- (4- fluorophenyl)- 2- oxo- 1,2- dihydropyridine- 3- carboxamideIBA 05/2014 - 05/2013
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2012 - 04/2007
3	CaspasesIBA 01/2012 - 05/2009
3	Death Domain ReceptorsIBA 01/2012 - 07/2009
3	25-hydroxyprotopanaxadiolIBA 01/2011 - 06/2008
3	Paclitaxel (Taxol)FDA LinkGeneric 12/2003 - 01/2002
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2024 - 12/2023
2	CarbamatesIBA 01/2024 - 12/2023
2	EnzymesIBA 01/2021 - 10/2015
2	Peptides (Polypeptides)IBA 01/2020 - 01/2005
2	Protein Isoforms (Isoforms)IBA 01/2020 - 12/2014
2	MA242IBA 10/2019 - 10/2018
2	Proteasome Endopeptidase Complex (Proteasome)IBA 05/2018 - 03/2014
2	Disulfiram (Antabuse)FDA Link 01/2018 - 03/2014
2	AndrogensIBA 01/2017 - 09/2008
2	artenimol (dihydroartemisinin)IBA 01/2017 - 07/2009
2	Monoclonal AntibodiesIBA 04/2016 - 01/2015
2	AntibodiesIBA 01/2015 - 01/2005
2	Tyrosine Kinase InhibitorsIBA 05/2014 - 05/2013
2	A-Form DNA (A-DNA)IBA 05/2014 - 03/2014
2	(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA 05/2014 - 01/2014
2	Aurora Kinase BIBA 01/2014 - 05/2013
2	LigandsIBA 07/2013 - 09/2006
2	Small Interfering RNA (siRNA)IBA 05/2013 - 11/2005
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2012 - 01/2005
2	AlkaloidsIBA 01/2011 - 05/2009
2	Toll-Like Receptor 9IBA 06/2007 - 06/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2007 - 09/2006
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 04/2007 - 07/2002
2	Nucleic AcidsIBA 05/2006 - 01/2005
2	E2F Transcription FactorsIBA 11/2005 - 09/2003
1	LipopolysaccharidesIBA 12/2023
1	Cholinesterases (Cholinesterase)IBA 12/2023
1	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 12/2022
1	Glucose (Dextrose)FDA LinkGeneric 10/2021
1	ResveratrolIBA 10/2021
1	Tumor Suppressor Protein p14ARF (p14ARF)IBA 01/2021

Therapy/Procedure

75	Therapeutics 05/2024 - 01/2002
21	Drug Therapy (Chemotherapy) 08/2023 - 09/2003
10	Investigational Therapies (Experimental Therapy) 01/2017 - 02/2003
7	Radiotherapy 01/2015 - 12/2003
1	Intravenous Administration 10/2021